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| 电子细胞模型Analog-Cell 中前体mRNA 剪接过程的模拟与研究 |
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欧阳丹彤1,2, 王珏1,2, 韩霄松1,2, 卢欣华1,2
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1.吉林大学 计算机科学与技术学院,吉林 长春 130012;2.吉林大学 符号计算与知识工程教育部重点实验室,吉林 长春 130012
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| 摘要: |
| 真核细胞前体mRNA的剪接加工包含内含子剪切和外显子拼接两个过程,是真核细胞基因表达过程中的一个重要环节.针对这一环节,提出了一种模拟真核细胞前体mRNA 内含子剪切及其选择性剪接的算法,并在自主研发的电子细胞模型Analog-Cell 中实现了该算法,且获得了符合生物学原理的模拟结果.模拟结果表明,该算法可使剪接体高效、准确地模拟内含子的剪接过程,并形成套索结构,同时有选择地将外显子片段拼接起来,最终形成成熟的mRNA. |
| 关键词: 电子细胞 Analog-Cell 选择性剪接 前体mRNA 的剪接 |
| DOI：10.3724/SP.J.1001.2012.04121 |
| 分类号: |
| 基金项目:国家自然科学基金(60973089, 61133011, 61170092, 61003101); 吉林省科技发展计划(20101501, 20100185); 浙江省自然科学基金(Y1100191); 吉林大学符号计算与知识工程教育部重点实验室开放项目(93K-17-2009-K05); 欧盟合作项目(155776-EM-1-2009-1-IT-ERAMUNDUS-ECW-L12) |
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| Simulation and Research on Pre-mRNA Splicing in Analog-Cell |
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OUYANG Dan-Tong1,2, WANG Jue1,2, HAN Xiao-Song1,2, LU Xin-Hua1,2
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1.College of Computer Science and Technology, Jilin University, Changchun 130012, China;2.Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun 130012, China
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| Abstract: |
| Pre-mRNA splicing is a key process in the gene expression of eukaryotic cells, which includes two major procedures: the cutting of introns and the union of exons. This paper proposes a algorithm to simulate the Pre-mRNA splicing process in the Analog-Cell, which was developed independently. Using the algorithm, the correct results are consistent with the biological principles. Through simulation of the process, the study has found that this algorithm has the capacity to make the introns to form the lariat structure efficiently and accurately, meanwhile to unit the exons selectively. In this way, the Analog-Cell can finish the formation of the mature mRNA. |
| Key words: electronic cell Analog-Cell alternative splicing pre-mRNA splicing |
