This paper investigates cache routing and cache management problems for en-route transcoding caching systems. An active cache routing algorithm called CCRA (cost-aware cache routing algorithm) is designed, which, using a controllable probing load, can find the potential cache objects with minimal access cost. Then an analyzable model for en-route transcoding caching is established, with which the cooperative cache placement and replacement problem is formulated as an optimization problem and the optimal locations to cache the object are obtained by using a dynamic programming algorithm. Results of the simulation show that the proposed scheme outperforms existing meta placement algorithms on metric of CSR (cost save ratio).